8,11,13 Furthermore, increased proliferation and survival of neurons in the hippocampus mediates learning enhancements.13,15 These studies indicate that the hippocampus remains highly modifiable throughout the lifespan and that exercise has the capacity to take advantage of the plasticity of this structure. Cell proliferation in the hippocampus leads to an increased demand Inhibitors,research,lifescience,medical for nutrients to support the new neural architecture. These regions acquire nutrients through

increased vascularization of neural tissue. After exercise, increased vascularization has been routinely found in several different brain regions including the cerebellum, motor cortex, hippocampus, and frontal cortex.16-18 Increased proliferation of cells and capillaries

in the hippocampus work in concert to enhance learning and memory in behavioral paradigms,19 but these effects can also be observed on the neurophysiological level. Inhibitors,research,lifescience,medical For example, exercise increases the number of synapses in the hippocampus,20 Inhibitors,research,lifescience,medical enhances indices of long-term memory formation,20 and elevates the rate of gene expression for molecules associated with learning and TWS119 order memory20 such as brain-derived neurotrophic factor (BDNF) and serotonin.8 It is clear from this literature that exercise influences the integrity of the hippocampus by influencing gene expression, cell proliferation and survival, vascularization, Inhibitors,research,lifescience,medical and synaptic plasticity. However, this literature has identified many different brain regions influenced by exercise, indicating that exercise has widespread effects. In conclusion, there are many different

molecular and cellular pathways mediating the effects of exercise on cognitive and behavioral outcomes, including increased neurogenesis, angiogenesis, and the production Inhibitors,research,lifescience,medical of growth factors important in memory and cognitive function. Effects of physical activity on cognitive function in humans Greater amounts of physical activity and higher cardiorespiratory fitness levels are associated with better cognitive function in older adults. For example, older adult athletes outperform their more sedentary peers on Histone demethylase many different cognitive tasks,21 and fitter individuals are faster and more accurate on executive functioning and memory tasks.22 Longitudinal studies of physical activity have also found that engaging in a greater amount of physical activity earlier in life is associated with better cognitive function later in life,23 with larger effects for individuals engaging in more intense exercises. However, cross-sectional and longitudinal observational studies are often plagued by confounding factors that make it challenging to make causal claims about the link between physical activity and cognitive function.