(C) 2009 Society of Chemical Industry”
“Objective: The study was aimed to compare trace elements concentrations in women with and without severe pre-eclampsia (PE). Methods: A prospective
case-control study was conducted comparing 43 parturients with severe PE (who received magnesium p38 kinase assay sulfate [MgSO4]) and 80 healthy parturients and their newborns, matched for gestational age and mode of delivery. Inductively coupled plasma mass spectrometry (ICPMS) was used for the determination of zinc (Zn), copper (Cu), selenium (Se) and magnesium (Mg) levels in maternal as well as arterial and venous umbilical cord serum. Results: Zn levels (mu g/L) were significantly higher in fetal arterial and venous blood of the PE group (947.3 +/- 42.5 vs. 543.1 +/- 226, 911.1 +/- 220.2 vs. 422.4 +/- 145, p < 0.001; respectively). Se levels (mu g/L) were significantly lower in maternal and fetal arterial and venous cord
blood of the PE group (98.6 +/- 24.2, 110.7 +/- 19.4, 82 +/- 17.8 vs. 111.6 +/- 17.6, 82.1 +/- 17.4 vs. 107.1 +/- 25.7, p < 0.001; respectively). Cu levels (mu g/L) were significantly lower in fetal arterial and venous cord blood (581.6 +/- 367.4 vs. 949 +/- 788.8, p = 0.022, 608.3 +/- 418.1 vs. 866.9 +/- 812.6, p = 0.001 respectively) but higher in maternal blood (2264.6 +/- 751.7 vs. 1048 +/- 851.1, p < 0.001). These differences www.selleckchem.com/products/cl-amidine.html remained significant while controlling for the mode of delivery. Mg levels were significantly higher in the PE group as compared with the control group. Conclusions: Severe PE is associated with abnormal concentrations of Zn, Cu and Se. Therefore,
trace elements may have a crucial role in the pathogenesis of severe PE.”
“Objective: The initial assessment of metabolic acidosis in subjects with diabetic ketoacidosis (DKA) is arterial blood gas analysis. This process is expensive, painful, and technically difficult. Furthermore, blood gas analysis may not be available in some facilities, especially in developing countries where DKA-associated morbidity and mortality remain high. Therefore, GDC-0068 mouse we investigated the utility of venous bicarbonate concentration obtained from a basic metabolic panel in predicting arterial pH in adults with DKA.
Methods: We performed a retrospective analysis of clinical and biochemical data of 396 adults admitted to 2 community teaching hospitals with DKA. We determined the correlation between arterial pH and venous serum parameters. Using multiple logistic regression, we obtained a predictive formula for arterial pH from serum venous bicarbonate level.
Results: The patient population was 59.0% male and had a mean age of 36.7 +/- 13.3 years. We derived that arterial pH = 6.97 + (0.