For 40 random spot urine samples, they reported a maximum urinary concentration of 0.93 μg/l oxo-MPHP. Most of the currently available human biomonitoring data (summarized e.g., in Wittassek et al., 2007, Wittassek et al., 2011, Koch and Calafat, 2009 and Kasper-Sonnenberg HIF cancer et al., 2012) do not distinguish between oxidized C10
metabolites of DIDP/DINP and DPHP due to the limited chromatographic resolution of the HPLC–MS methodology applied. The C10-metabolite levels from these studies, however, indicate a cumulative C10-phthalate exposure (DINP/DIDP and DPHP) that is considerably higher than that for DPHP alone. Future studies using differential integration of specific DPHP metabolites next to the cumulative measurement of C10-phthalate metabolites have to confirm this finding. None for all authors
except for A. Langsch and R. Otter who both are employed by BASF SE, a producer of DPHP. Transparency Document. The study was carried out as part of a ten-year project on selleck chemical human biomonitoring. The project is a cooperation agreed in 2010 between the Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) and the Verband der chemischen Industrie e.V. (German Chemical Industry Association – VCI); it is administered by the Federal Environment Agency (UBA). The study aims to characterize suitable biomarkers for human biomonitoring and to develop a new analytical method based upon these biomarkers and was funded by the German Chemicals Industry. Experts from government authorities, industry and science accompany the project in selecting substances and developing methods. “
“The chlorophenoxy compounds 4-chloro-2-methylphenoxyacetic acid (MCPA) and 2,4-dichlorophenoxyacetic acid (2,4-D) are selective herbicides used in agricultural and household sectors worldwide. 2,4-D is the most commonly used chlorophenoxy herbicide in the US (Kiely et al., 2004) and acute self-poisoning with MCPA is a common reason for presentation to rural hospitals in Sri Lanka where subsistence farming is common (Roberts et al., 2005). Severe poisoning including coma, rhabdomyolysis
and renal toxicity may occur and persist for some days. Death occurs in around 5% of patients and is typically 24–48 h post-ingestion Ceramide glucosyltransferase (Roberts et al., 2005). The mechanism of fatal toxicity has not been defined (Roberts et al., 2005). Animal studies have also suggested that prolonged elimination of chlorophenoxy herbicides leads to increased toxicity (Timchalk, 2004). Further, saturation of protein binding increases the free (unbound) concentration of the poison, which is then available to distribute from the plasma (central) compartment. In the case of chlorophenoxy compounds, this is important because the mechanism of toxicity is thought to relate to disruption of intracellular processes (Roberts and Buckley, 2007a).