In contrast, Rovner and colleagues39 attribute the maintenance of the effect of the intervention in their study to an ongoing requirement for physicians to complete an “indications and side effects” document for each resident receiving psychoactive medication.39 This is the first systematic review to specifically synthesize evidence of the effectiveness of interventions to reduce inappropriate prescribing of antipsychotics to people with dementia resident in care homes. Irrespective of the nature of the intervention, in the studies with the most robust design, antipsychotic prescription

rates were seen to fall as a result of the intervention. Although, more difficult to interpret, similar effects were ISRIB manufacturer also seen in the less well-designed studies. There is little information in the included studies to aid understanding of the sustainability of the effects of interventions. Furthermore, one of the striking features of this body of literature is that it spans 27 years, with the earliest trial reported in 1987. Over this period, there have been a variety of initiatives, including changes in regulations and widely disseminated guidance aimed at limiting the use of these agents, but evidently prescribers still find compelling reasons to use them. This work highlights 2 key issues that have been illustrated in previous systematic reviews of

related areas: (1) the challenges of changing practice within care homes and (2) the scarcity of good-quality research conducted in this setting. This body of literature PARP inhibitor spans an extended time period during which research and reporting methods have improved considerably; however, 6 of the included before and after studies were conducted

within the last 4 years. We specifically searched for qualitative information on the views and experiences of prescribers using the included interventions, but disappointingly were unable to locate any articles meeting our inclusion criteria. Studies exploring factors that influence prescribing behavior more generally suggest a variety of factors may be involved. These include shortfalls in time, staffing levels, and staff training that impact on nonpharmacological alternatives ID-8 to antipsychotic medication being considered viable, a pressure from family members and carers to prescribe and a misconception of the likelihood that an individual might benefit from antipsychotic medication.40, 41, 42, 43 and 44 Other studies that have looked at implementation of interventions for other purposes in care home settings have identified the importance of involving family members in decision-making in the successful management of behavioral problems45 and the management of incontinence.46 A systematic review of the implementation of psychosocial interventions for people with dementia in care homes found that active engagement of care-home staff and family members played a crucial role in successful implementation.