In this Greater Cincinnati/Northern Kentucky population-based stu

In this Greater Cincinnati/Northern Kentucky population-based study, 8% were eligible. However, no established therapy exists for children with acute ischemic stroke. Accordingly, investigators assessed rates of eligibility for recombinant tissue plasminogen activator therapy among children (< 18 years of age) in the same population to aid planning of future clinical trials. The investigators identified 29 pediatric ischemic

strokes during 3 separate study periods (1993-1994, 1999, and 2005) and determined potential eligibility for recombinant mTOR inhibitor tissue plasminogen activator therapy based on 2007 American Heart Association guidelines for adults. Depending on how relative contraindications were considered, 1 to 3 cases (3%-10%) met eligibility criteria. On the basis of national pediatric stroke incidence rates extrapolated from our population, it is estimated that up to 178 children might be eligible for intravenous recombinant tissue plasminogen activator therapy annually in the United States. Thus, recruitment for clinical studies is likely to be challenging and requires a concerted multicenter effort.”
“Within a single-center prospective cohort study of neonatal encephalopathy involving 315 subjects, 15 neonates were found to have a

focal stroke on magnetic resonance imaging. These 15 patients were matched on the basis of gender and degree of encephalopathy to 30 neonates buy MK-2206 without stroke from the same cohort. On Bayley Scales of Infant Development, the stroke group had Mental Development Index scores that were 1.7 standard deviations lower compared with controls (P = .007). This BAY 80-6946 order association was no longer seen after adjustment for the presence of neonatal seizures (P = .11). Of the 15 patients with stroke, 5 had been treated with hypothermia. None of these 5 had seizures in the neonatal period, compared with 7 of the untreated 10. This is the first human study to demonstrate a potential treatment effect of therapeutic hypothermia

on perinatal stroke. It was also shown that seizures are associated with worse cognitive outcomes for stroke that presents with encephalopathy.”
“Objective. Candida albicans has been a common isolate in posttreatment disease, usually as a monoinfection of the root filled canal. A factor likely to contribute to its pathogenic potential in posttreatment infection is an ability to endure starvation and use serum as a nutritional source. This study evaluated the starvation-survival behavior, growth, and recovery in human serum of C. albicans and compared it with Enterococcus faecalis.

Study design. Varying cell densities of C. albicans and E. faecalis were suspended in 5% human serum or water for 4-6 months. Starvation recovery was assessed by addition of 50% serum to starved cells. Cell survival was monitored by periodic removal of aliquots and viable counts.

Results. Initial cell density was important for starvation survival.

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