Material and method: We studied retrospectively a cohort of 143 UC patients, who never received immunosuppressive drugs, and treated for the first time with oral corticosteroids for a flare. Among patients responding to corticosteroids, we studied the group treated by mesalazine after the flare.
Results: Fifty% (n=52) achieved a complete clinical remission with steroid weaning. In this group, 67% (n =35) received oral mesalazine. Seventy-five % of patients treated by mesalazine relapsed (median 29 months, range: 1-156). Fourteen % required a colectomy (median 11 months, range: 1-24). Kaplan
Meier curve showed a relapse https://www.selleckchem.com/products/CX-6258.html rate and a colectomy rate over one year of 26% and 11% respectively. In multivariate analysis, male gender and short duration Staurosporine concentration of disease were predictive factors of the time-to-relapse. No factor was predictive of time-to-colectomy.
Conclusion: Maintenance efficacy of mesalazine over one year after a first course of corticosteroids for a disease flare is reasonably high.
The longer-term relapse rate becomes higher in male patients with a short disease duration. An immunosuppressive treatment could be discussed in case of further relapse despite improved medication-adherence. Medication-adherence should first be assessed and promoted. An immunosuppressive treatment could be discussed in case of further relapse despite improved medication-adherence. (C) 2011 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Objective: Prostate cancer (PCa) patients often must decide between several treatment modalities considered equally efficacious, but associated with different benefits and side-effects. For some, the decision-making process can be difficult, but little is known about patient characteristics and cognitive processes that might influence the difficulty of such decisions. This study investigated the roles of dispositional optimism and self-efficacy in
PCa treatment decision-making difficulty and satisfaction.
Methods: One hundred and twenty-five patients with clinically localized PCa completed a mail-in find more paper-and-pencil survey after they had made their treatment decision, but prior to treatment.
Results: After adjusting for covariates, optimism and treatment decision-making self-efficacy were associated with less difficult), and greater satisfaction with the treatment decision-making process. Effects of optimism on difficulty and satisfaction were partially mediated by self-efficacy for making the treatment decision.
Conclusions: Men with PCa and who are low in optimism may be at greater risk for treatment decision-making difficulty and lack of treatment decision-making satisfaction, in part, because the), have lower confidence in their ability to make the decision compared with those who are more optimistic.