Moreover, visfatin levels also correlated with hsCRP levels and carotid IMT, suggesting that visfatin may play an important role in uremia-related atherosclerosis.”
“The standard technique using lymphoscintigraphy, blue dye and a gamma probe has established a reliable method for sentinel node biopsy for skin cancer. However, the detection rate of cervical sentinel lymph nodes (SLN) is generally lower than that of inguinal or axillary SLN because of the complexity of lymphatic drainage in the head and neck region and the shine-through phenomenon. Recently, indocyanine green fluorescence imaging has been reported as a new method to detect SLN. We hypothesized that fluorescence
navigation with indocyanine LY3023414 mouse green in combination Bafilomycin A1 clinical trial with the standard technique would improve the detection rate of cervical sentinel nodes. We performed cervical sentinel node biopsies using the standard technique
in 20 basins of 18 patients (group A) and using fluorescence navigation in combination with the standard technique in 12 basins of 16 patients (group B). The mean number of sentinel nodes was two per basin (range, 1-4) in group A and three per basin (range, 1-5) in group B. The detection rate of sentinel nodes was 83% (29/35) in group A and 95% (36/38) in group B. The false-negative rate was 6% (1/18 patients) in group A and 0% in group B. Fluorescence navigation with indocyanine green may improve the cervical sentinel node detection rate. However, greater collection of data regarding the usefulness of cervical sentinel node biopsy using indocyanine green is necessary.”
“Objective: To study hypoxia-inducible factor pathway the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients.
Design: Case-control association study.
Methods:
132 patients with baseline peritoneal equilibration test within 1-3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-alpha; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates.
Results: The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype (n = 18) had significantly lower D-4/P creatinine (0.65 +/- 0.087 vs 0.73 +/- 0.110, p = 0.0046) and higher D-4/D-0 glucose (0.39 +/- 0.174 vs 0.31 +/- 0.119, p = 0.027) than patients with TT genotype (n = 114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D-4/P creatinine (r(2) = 0.1294, p < 0.0001) and was significantly lower in the TA genotype than the TT genotype (201.