Results: The aptamers could be clustered into 4 subgroups, and the correlation coefficients between aptamers were from 0.009 to 0.707, indicating that most of these aptamers have different targets in PHC serum. The results of aptamer assay were significantly correlated with some clinical Cabozantinib and laboratory parameters, such as 8 aptamers with liver cirrhosis background, 7 aptamers with liver function, 7 aptamers with international normalized rate (INR), 6 aptamers with tumor size, 6 aptamers with blood platelet count, 4 aptamers with total bilirubin. The patients could be clustered into 2-4 subgroups

with the results of aptamer assay. Some clinical and laboratory parameters were significantly different between or among subgroups (P < 0.05∼0.01). This is the first attempt of molecular classification by aptamer assay. Conclusion: Primary hepatic carcinoma could be clustered into subgroups with the results of aptamer assay, suggesting that aptamer-based molecular classification of PHC has feasibility and clinical value. Key Word(s): 1. Aptamer; 2. classification; 3. Correlation; 4. hepatoma; Presenting Author: SHIFTEH ABEDIAN Additional Authors: MEHDISABERI FIROOZI, REZA MALEKZADEH Corresponding Author: SHIFTEH ABEDIAN, MEHDISABERI FIROOZI Affiliations: TUMS(DDRI) Objective: Hepatocellular Carcinoma Doxorubicin molecular weight (HCC) is the sixth common cancer in world. In order to define the characteristics of HCC in our country we studied

the cases that have been admitted in a large referral gastroenterology ward during 2000-2011. Methods: The discharge sheets of 7000 patients had been admitted in Shariati hospital GI ward during this period were reviewed. We defined and coded the final diagnosis on the basis of ICD-10 and then extracted the etiologic causes-outcome and other demographic data of HCC from discharge notes. The not diagnosis of HCC was done according to liver biopsy or typical imaging studies according to international guidelines. Results: 7000 patients admitted during this time in GI

Ward that 3.4% of them had HCC. 74% of these patients were men (age 55.81 ± 4.91 years) and 26% were women (age 53.61 ± 17.30 years). The mortality rate in this group was 17.2%. In women the common etiologies were related to: cryptogenic (47.36%), Hepatitis B virus (HBV) (39.48%), cholestatic liver disease in 7.89% and hepatitis C virus (HCV) in 5.57%. In men 62.03% of HCC was related to HBV, 22.22% to cryptogenic, 10.19% to HCV. The most common presentations in these patients were ascites and spontaneous bacterial peritonitis (48.8%), hepatic encephalopathy (24%), variceal bleeding (12%) and hepatorenal syndrome (2.5%). The most common presentations of patients who died were hepatic encephalopathy (41.8%), variceal bleeding (31.5%), ascites and/or spontaneous bacterial peritonitis (15%), and hepatorenal syndrome (5.2%). Conclusion: More than half of HCC is related to viral hepatitis and especially to HBV.