Systems biology offers ways to combine knowledge from these disci

Systems biology offers ways to combine knowledge from these disciplines by building integrative models that are quantitative and predictive. Can such models

be useful for gaining a deeper understanding of epithelial morphogenesis? Here, we take inventory of some recurring themes in epithelial morphogenesis that systems approaches could strive to capture. Predictive understanding of morphogenesis at the systems level would prove especially valuable for diseases such as cancer, where epithelial tissue architecture is profoundly disrupted. WIREs Syst Biol Med 2012, 4:5178. doi: 10.1002/wsbm.159″
“Huntington’s disease (HD) is a rare neurodegenerative disease with a multitude of symptoms, which requires selleckchem access to specialized multidisciplinary care for adequate management. The aim of this study was to survey the characteristics

of care in various HD centers in South America (SA). Methods: A questionnaire was sent to 24 centers involved in the care for HD patients in SA. Results: Of the total 24 centers, 19(79.2%) click here are academic units. The majority of centers (62.5%) are general movement disorders clinics. Multidisciplinary care is available in 19 (79.2%) centers and in 20 (83.3%) care is provided free of charge. Genetic testing and counseling are available in 25 and 66.6% of centers, respectively. The majority of centers (83.3%) have no institutional support for end-stage care. Conclusions: Although HD centers in SA are committed to providing multidisciplinary care, access to genetic counseling and end-stage care are lacking in most centers.”
“P>We present a case of endocarditis caused by Aspergillus in a lung transplant (LT) patient and review 6 previously reported cases. All cases were caused by Aspergillus fumigatus. Five patients Emricasan mouse (71%) were transplanted due to cystic fibrosis. None of the patients had any previously known valvular heart

disease. The time that elapsed between LT surgery and the diagnosis of Aspergillus endocarditis was 8 +/- 6 months. Large peripheral emboli were observed in 6 patients (85%); blood cultures were negative in all. Transthoracic echocardiography did not detect the presence of vegetations in 3 patients (43%); the vegetations measured > 1.5 cm in all cases. Five patients (71%) died from disseminated disease. Both survivors underwent combined therapy with antifungal drugs and surgical treatment.”
“Stroke represents the second common cause of death in adults. Objective: It was to evaluate the incidence and causes of mortality after 30 days in a group of patients with an atherothrombotic ischemic stroke who were followed-up for a period of up to two years. Methods: We analyzed retrospectively the medical records of patients with ischemic stroke, who did not undergo thrombolysis, of the Santa Marcelina Hospital. We applied a research protocol to obtain information about risk factors and the etiology of death. Results: They were followed 337: mean age was 66.6 years (SD 9.

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