g. basal cell hyperplasia, papillary elongation, ISD, infiltration with intraepithelial eosinophils, neutrophils, and mononuclear cells etc.). Results: The light microscopy quantitative analysis showed that the mean ISD value of GERD was larger than that in FH and control (p < 0.05), and there was no statistically difference between

FH and control group (p = 0.13); According to the results of 24-hour pH impedance monitoring, the mean ISD value in the subjects with acid reflux was much higher than that of the subjects without acid reflux (p = 0.001). When the cut-off value for mean ISD was 0.90 μm, the sensitivity of GERD diagnosis was 65.6% and specificity was 56.8%, the total consistent rate was 62.9%. Two hundred and fifty-three were underwent the histological evaluation. When the optimal cut-off value was 3.5, the sensitivity was 55.2% and specificity was 60.5%, the total consistent PD-0332991 ic50 rate was 62.7%. Combination the ISD value and histological evaluation, the sensitivity of GERD diagnosis was 80.6% and specificity was 36.1%. Conclusion: The mean ISD value was

closely related to the acid reflux. The diagnostic value of the mean ISD value was as same as histological evaluation. Combination this two methods can only improve the sensitivity of diagnosis of GERD. Key Word(s): 1. GERD; 2. Histological scores; 3. ISD; 4. Function heartburn; Presenting Alisertib mw Author: TONGYU TANG Additional Authors: YUQIN LI, LIHONG MA Corresponding Author: TONGYU TANG Affiliations: No.1 hospital of jilinuniversity; Np.1 hospital of jilin university; NO.1hospital of jilin university Objective: Our aim was to study clinical classification

and characteristics among the different heartburn groups. Methods: All patients were initially evaluated by a symptom questionnaire under the guidance of digestive physician, and thereafter underwent an upper endoscopy, patients with damaged esophageal mucosa were classified into RE type in GERD group, those with normal-appearing esophageal mucosa were followed by ambulatory 24 h esophageal pH monitoring including counting symptom index and then administrated by PPI trial, those patients having a normal esophageal mucosa were stratified into NERD and FH based on 24 h esophageal pH monitoring, symptom index and PPI trial, and the last analyse the medchemexpress different Characteristics of different heartburn groups. Results: There was no statistically significant difference between three groups of age and gender. Combined with esophageal pH monitoring, symptom index and PPI trial, and NERD subdivided into 3 subgroups:20 patients were testified with excessive acid exposure; 13 patients were found with normal acid exposure and positive SI at the same time; the other 13 cases had positive PPI trial although they had normal pH monitoring and negative SI. After complete classification, comparing the differences in esophageal pH monitoring of different classification.