The most commonly reported TEAE was headache (vicriviroc + OC, n = 1; ritonavir + OC, n = 3; vicriviroc + ritonavir + OC, n = 2; OC alone, n = 12; placebo OC, n = 2). No TEAEs were considered severe.\n\nConclusions: In this population of healthy female subjects, vicriviroc had little effect on the pharmacokinetics of EE or NET, whereas ritonavir, alone Anlotinib price or with vicriviroc, was associated

with consistent decrease in exposure of EE and a lesser decrease in NET. (Clin Ther. 2011;33:1503-1514) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.”
“Seaweeds are inhabited by small mobile invertebrates that use their hosts as habitat, food and protection against predators. Patterns of distribution and abundance may therefore reflect complex trade-offs between suitable space, nutritional requirements and refuge. We tested differences in abundance and density of isopods (Idotea https://www.selleckchem.com/products/ink128.html baltica) in four different seaweed habitats (Furcellaria, Focus, Cladophora, Ulva; Island of

Bornholm, Baltic Sea) and experimentally assessed different ecological interactions between isopods and seaweeds. We found marked differences in abundance of isopods among seaweed habitats in the field, with a prevalence for form-functionally simple seaweeds. Patterns of isopod densities on seaweeds in the field resembled patterns of grazing and growth rates, but were opposite to habitat selection in laboratory experiments. Habitat VX-680 inhibitor selection resembled patterns of standing seaweed biomass and cover in the field. Laboratory experiments also showed that all seaweed habitats dramatically reduced fish predation on isopods regardless of seaweed identity. The strong affinity of isopods to seaweeds likely reflects predator avoidance whereas their selectivity between seaweeds could be due to grazing interactions and habitat availability. We therefore conclude that in situ patterns of isopod distribution and abundance, at least in part, reflect complex interactions between bottom-up (food type and availability) and top-down (predator refugia) forces. (C) 2013 Elsevier B.V. All rights reserved.”
“The New Zealand mud snail, Potamopyrgus

antipodarum, was found in four lakes and one medium-sized river located in the southern part of Lithuania during 2010. These are the first records of P. antipodarum from Lithuanian freshwaters, a considerable distance from the Curonian Lagoon wherein the species was reported during the 1950s. Available information shows that the species has invaded quite recently. Two morphotypes of the species, the regular and carinatus (keeled) forms, were observed in three lakes. The presence of separate morphotypes and variation in shell morphometry suggest multiple (at least two) independent invasion events, and species expansion on a local scale. The most abundant population of the invasive snail was recorded in Lake Dusia which is an inland lake of exceptional importance for staging and moulting of migratory waterfowl.

Intranasal gas (either air or oxygen) may provide a placebo benefit.”
“The asymmetric unit of the title compound, C14H10FN3OS2, contains two independent molecules which differ LY2835219 price in the relative orientations of

the triazole and allylsulfanyl groups with respect to the planar thiochromen-4-one frameworks. The N-N-C-C torsion angles are 128.2 (5) and -120.9 (5)degrees, while the C-S-C-S torsion angles are -17.4 (4) and 16.4 (4)degrees. In the crystal, intermolecular C-H center dot center dot center dot O and C-H center dot center dot center dot N hydrogen bonds link the molecules in a stacked arrangement along the a axis.”
“Background and objectives: In recent years, biochemical markers have been employed to predict the outcome of patients with traumatic brain injury (TBI). In mild TBI, S100B has shown the most promise as a marker Of Outcome. The objective of this study in patients with severe TBI was to: show the range of serum S100B levels during the acute phase after trauma: determine if S100B has potential to discriminate favourable from unfavourable Outcome in patients with similar brain injury severity scores and to establish an S100B ‘cut-off’ predictive for death.\n\nMethods: All patients

with severe TBI, admitted to this neurointensive care unit within 24h of injury were eligible for inclusion in the study. One serum blood sample was obtained from each patient at the 24 h post-injury time-point. S100B levels were measured using Erastin cell line enzyme-linked immunosorbent assay. Injuries were coded using an internationally recognised injury severity scoring system Selleck PD98059 (ISS). Three-month follow-tip was undertaken

with outcome assessed using the Glasgow outcome Score (GOS).\n\nResults: One hundred patients were recruited. Serum S100B levels ranged from 0.08 to 12.62 mu g L(-1) S100B levels were significantly higher in patients with a GOS of 1 (death) 2 and 3 (unfavourable outcome) compared with those with GOS 4 and 5 (good recovery). In this study a cut-off point of 0.53 mu g L(-1) has sensitivity of >80% and specificity of 60% to predict unfavourable Outcome and 49% to predict death.\n\nConclusion: In 100 patients studied with similar brain injury severity scores, serum S100B measured at the 24-h time-point after injury is significantly associated with Outcome but a cut-off 0.53 mu g L(-1) does not have good prognostic performance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Aims. The non-invasive C-13-methacetin (C-13-MBT) breath test has been proposed as a measure of metabolic liver function that improves the diagnostic efficacy of serologic and biochemical tests in assessing hepatic functional capacity and liver disease severity, The goal of this study was to establish the clinical utility of this test in quantifying hepatic metabolic function in patients with liver cirrhosis of varying severity and to compare C-13-MBT measurements with the AST/ALT ratio, APRI score, and other routine liver tests.\n\nMethods.

Using rate-4 undersampling, BLOSM was compared with other CS methods such as k-t SLR that uses matrix low-rank sparsity applied to the whole image dataset,

with and without motion tracking, and to k-t FOCUSS with motion estimation and compensation that uses spatial and temporal-frequency sparsity. ResultsBLOSM was qualitatively shown to reduce respiratory artifact compared with other methods. Quantitatively, using root mean squared error and the structural similarity index, BLOSM was superior to other methods. ConclusionBLOSM, which exploits regional low-rank structure and uses region tracking for motion compensation, provides improved image quality for CS-accelerated first-pass cardiac MRI. Magn Reson Med 72:1028-1038, 2014. (c) 2013 Wiley Periodicals, GSK1120212 Inc.”
“Lead (Pb), as a major environmental contaminant, could be harmful to humans when inhaled or ingested. In this study, we developed a selleck kinase inhibitor sensitive, selective and fast colorimetric aptasensor for Pb+2 based on polyethylenimine (PEI) and gold nanoparticles (AuNPs). In the absence of Pb+2, aptamer binds to PEI. So the well-dispersed AuNPs remain stable with a wine-red color. Upon the addition of Pb+2, a conformational change happens and a G-quadruplex aptamer/Pb+2 complex is formed,

leading to the aggregation of AuNPs and a color change to blue. This sensor showed a high selectivity toward Pb+2 with a limit of detection (LOD) as low as 702 pM. Moreover, our fabricated sensor was successfully applied for Pb+2 detection in rat serum and tap water. (C) 2015 Elsevier B.V. All rights reserved.”
“We determined the frequency of gallstones (GS) in iron deficiency anemia (IDA) patients and evaluated factors that could affect GS formation-like lipid levels and gallbladder

(GB) motilities of the patients. One hundred and eleven IDA patients (88 females, 23 males; median age, 42) and 81 healthy controls (68 females, 13 males; median age, 42) were included into our study. The clinical findings of all IDA patients were recorded down; biochemical values and body mass index (BMI) were determined; and abdominal ultrasonography was performed. In addition, GB emptying was monitored by ultrasound at 30-min intervals for 2 h after a mixed meal in randomly chosen, age-matched https://www.selleckchem.com/products/sc79.html 25 IDA patients and 26 controls. Fasting volume (FV), residual volume (RV), and ejection fraction (EF) for all GBs were determined. The frequency of GS plus cholecystectomy was significantly higher in IDA patients (15 cases, 13.5%) than in the control group (five cases, 6.2%, p=0.048). IDA patients with GS plus cholecystectomy were older than those without GS plus cholecystectomy (p<0.001). FV and EF did not differ between IDA and control groups (p>0.05). On the other hand, RV was significantly higher in IDA group than in controls (p=0.035). The frequency of GS in IDA patients was significantly higher than in controls.

“
“The presence of both cytoplasmic and nuclear genomes within eukaryotic cells raises fascinating questions about co-evolution between genomic compartments that experience fundamentally different mutation rates and modes of inheritance. The highly mutagenic environments found in the mitochondria of some eukaryotes have generated interest in the role that mitochondrial mutation accumulation plays in phenomena such as intracellular gene HKI272 transfer, compensatory evolution in the nucleus and the evolution of reproductive isolation. Although plant systems have

played an important historical role in the study of cytonuclear co-evolution, they remain underutilized in many respects. In particular, the enormous natural variation in DNA substitution rates, gene content and genome architecture in plant mitochondria – much of which has even been found within a single genus – provides opportunities to resolve longstanding evolutionary questions about the consequences of mitochondrial mutation accumulation. This review summarizes some of the classic questions about cytonuclear co-evolution that could be addressed by taking advantage of the variation in plants and highlights A-769662 concentration a recent analysis of the effect of mitochondrial mutation accumulation on rates of molecular evolution in the nucleus.”
“Endosomal sorting complexes required for transport (ESCRT-0, ESCRT-I,

ESCRT-II, and ESCRT-III) are selectively recruited to cellular membranes to exert their function in diverse processes, such as multivesicular body biogenesis, enveloped virus budding,

and cytokinesis. ESCRT-III is composed of members of the charged multivesicular body protein selleck (CHMP) family-cytosolic proteins that are targeted to membranes via yet unknown signals. Membrane targeting is thought to result in a membrane-associated protein network that presumably acts at a late budding step. Here we provide structural evidence based on small-angle X-ray scattering data that ESCRT-III CHMP3 can adopt two conformations in solution: a closed globular form that most likely represents the cytosolic conformation and an open extended conformation that might represent the activated form of CHMP3. Both the closed and open conformations of CHMP3 interact with AMSH with high affinity. Although the C-terminal region of CHMP3 is required for AMSH interaction, a peptide thereof reveals only weak binding to AMSH, suggesting that other regions of CHMP3 contribute to the high-affinity interaction. Thus, AMSH, including its MIT (microtubule interacting and transport) domain, interacts with ESCRT-III CHMP3 differently from reported Vps4 MIT domain-CHMP protein interactions. (c) 2008 Elsevier Ltd. All rights reserved.”
“The University of Kansas High-Throughput Screening (KU HTS) core is a state-of-the-art drug-discovery facility with an entrepreneurial open-service policy, which provides centralized resources supporting public-and private-sector research initiatives.

This study shows that an important factor correlating

with growth variation is the duration of corneo-scleral tissue in organ culture. Interestingly, donor age was not correlated with limbal explant growth. J. Cell. Physiol. (C) 2012 Wiley Periodicals, Inc.”
“Multifunctional nanoparticles have been developed to overcome the conventional hurdles associated with the diagnosis and treatment of disease. However, there are often caveats involved with the development and clinical translation of multifunctional nanoparticles largely regarding the notion that additional functionality increases nanoparticle complexity. Here, we discuss two design concepts, a conventional approach, all-in-one’, and introduce the concept of one-for-all’ to suggest that multifunctionality does not necessarily result in AC220 solubility dmso multicomponent complex nanoparticles. This review focuses on the design concepts of all-in-one and one-for-all with examples of each approach and a discussion on the implications for clinical translation. WIREs Nanomed Nanobiotechnol 2013, 5:250265. doi: 10.1002/wnan.1217 For further resources related to this article, please visit the WIREs website.”
“We report the efficient photoelectrocatalytic (PEC) reduction of Cr(VI) using TiO2 nanotubes (TNTs) as the photoanode and a large-area Ti mesh as the photocathode. Short-length TNTs (S-TNTs) selleck chemical show much greater PEC activity than

either long-length TNTs (L-TNTs) or sol-gel-prepared TiO2 film, due to the fact that the TNT structure is advantageous of trapping light energy over the thin-film structure and the S-TNTs enable the more efficient electron transfer into the substrate than L-TNTs. More importantly, increasing the surface area of the photocathode (Ti mesh) can greatly accelerate the PEC reduction of Cr(VI), presumably due to the increased number of the active reduction sites on the larger-surface Ti mesh. In the PEC reduction of Cr(VI), Cr(V) is identified as a

reaction intermediate using the electroparamagnetic resonance technique, whereby the process for the Cr(VI) evolution is proposed. The S-TNTs have been confirmed to be stable over many repetitive cycles of use, indicating their suitability for wide-scale use. (C) 2010 Elsevier B.V. All rights reserved.”
“Sources and sinks of methane, one of the most important greenhouse gases, have attracted intensive attention selleck compound due to its role in global warming. We show that sea ice in the Arctic Ocean regulates methane level through two mechanisms, shielding of methane emission from the ocean, and consumption of methane. Using a static chamber technique, we estimated that the methane flux from under-ice water was 0.56 mg(CH4) m(-2) d(-1) on average in central Arctic Ocean, relatively higher than that in other oceans, indicating considerable methane storage in this region under sea ice. Average methane flux on under-ice water was higher than that above sea ice, which suggests that sea ice could limit methane emission.

Research sample was selected by a multistage cluster sampling. The data was obtained by using a valid reliable questionnaire for measuring the perceptions, a checklist for observing the quality of brushing and dental flossing and health files

and clinical observation. First, a descriptive study was applied to individual perceptions, oral behaviors, Oral Hygiene Index (OHI) and Decayed, Missing DAPT ic50 and Filled Teeth Index (DMFTI). Then an educational planning based on the results and Health Belief Model (HBM) was applied. The procedure was repeated after six months.\n\nResults: After education, based on HBM, all the oral health perceptions increased (P<.05). Correct brushing and flossing are influenced by increased perceptions. A low correlation between the reduction of DMFTI and increased perceived find more severity and increased perceived barriers are found (r = -0.28, r = 0.43 respectively). In addition, there was a limited correlation between OHI and increased perceived benefits (r = -0.26).\n\nConclusion: Using health belief model in oral health education for increasing the likelihood of taking preventive oral health behaviors is applicable.”
“The information provided by the International Commission for the Conservation of Atlantic Tunas (ICCAT) on captures of skipjack tuna (Katsuwonus pelamis)

in the central-east Atlantic has a number of limitations, such as gaps in the statistics for certain fleets and the level of spatiotemporal detail at which catches are reported. As a result, the quality of these data and their effectiveness for providing management

advice is limited. In order to reconstruct missing spatiotemporal data of catches, the present study uses Data INterpolating this website Empirical Orthogonal Functions (DINEOF), a technique for missing data reconstruction, applied here for the first time to fisheries data. DINEOF is based on an Empirical Orthogonal Functions decomposition performed with a Lanczos method. DINEOF was tested with different amounts of missing data, intentionally removing values from 3.4% to 95.2% of data loss, and then compared with the same data set with no missing data. These validation analyses show that DINEOF is a reliable methodological approach of data reconstruction for the purposes of fishery management advice, even when the amount of missing data is very high.”
“Key points Using a diet-induced obese rat model, we examined two sympathoinhibitory reflexes: the baroreflex and the reflex induced by the gastrointestinal hormone cholecystokinin (CCK). The change in neuronal discharge of presympathetic vasomotor neurons in the rostroventrolateral medulla (RVLM) to both sympathoinhibitory stimuli was significantly blunted in obesity-prone (OP) hypertensive animals when compared to obesity-resistant (OR) animals or controls on a low fat diet, at the single neuronal level.

\n\nMethods In nine healthy volunteers, 15 min

and 4 h planar thoracic scintigrams and conjugate whole-body scans were performed up to 48 h following intravenous injection of 185 MBq I-123-MIBG. The subjects were given both nca and ca I-123-MIBG. Early heart/mediastinal ratios (H/M), late H/M ratios and myocardial washout were calculated. The fraction of administered activity in ten source organs was quantified from the attenuation-corrected geometric mean counts in conjugate views. Radiation-absorbed doses were estimated with OLINDA/EXM software.\n\nResults Both early and late H/M were higher for nca I-123-MIBG (ca I-123-MIBG early H/M 2.46 +/- 0.15 vs nca I-123-MIBG 2.84 +/- 0.15, p = 0.001 and ca I-123-MIBG late H/M 2.69 +/- 0.14 vs nca I-123-MIBG https://www.selleckchem.com/products/MDV3100.html 3.34 +/- 0.18, p = 0.002). Myocardial washout showed a longer retention time for nca I-123-MIBG (p < 0.001). The effective dose equivalent (adult male model) for nca I-123-MIBG

was similar to that for ca I-123-MIBG (0.025 +/- 0.002 mSv/MBq vs 0.026 +/- 0.002 mSv/MBq, p = 0.055, respectively).\n\nConclusion No-carrier-added I-123-MIBG yields a higher relative myocardial uptake and is associated with a higher myocardial retention. This difference between nca I-123-MIBG and ca I-123-MIBG in myocardial uptake did not result in major differences in estimated absorbed doses. Therefore, nca I-123-MIBG is to be preferred this website over ca I-123-MIBG for the assessment of cardiac sympathetic activity.”
“Eicosanoids are products of arachidonic acid metabolism and have numerous biological roles. The present study aimed to ivnestigate the fole of 5-lipoxygenase (5-LOX)- and cyclooxygenase-2 (COX-2)-

dependent enzymatic pathways in the pathogenesis of porcine parasitic bronchopneumonia caused by Metastrongylus spp. Pulmonary tissue samples from healthy control and parasitized pigs HDAC inhibitor were proessed for histophathological, immunohistochemical and bichemical investigations. In control animals, immunohistochemistry demonstrated that 5-LOX and COX-2 expression was almost exclusively limited to the bronchiolar epithelial cells. Paratsitized pigs had greated 5-LOX- and COX-2- specific immunoreactivity, involging a wide range or cell types within foci of granulamatous and eosinophilic bronchopneumonia. Biochemical investigations demonstrated the presence of 5-LOX (and the realted product Leukotriene B(4)) and COX-2 (and the related product prostaglandin E(2); PGE(2)) in all tissues under study. COX-2 activity and PGE(2) concentration were significantly higher in diseased lungs compared with normal healthy controls. These findings demonstrate that 5-LOX and COX-2 are differentially expressed in normal versus lungworm-infected lungs and therefore suggest that both biochemical pathways are likely to be involved in the pathogenesis of parcine parasitic bronchopneumonia (C) 2009 Elsevier Ltd.

The assemblage comprises several lungfish taxa, with the first mention of the occurrence of Arganodus tiguidiensis, and possibly two mawsoniid coelacanths. A large bichir, cf. Bawitius, is recorded and corresponds to cranial elements initially referred to ‘Stromerichthys’ from coeval deposits

in Egypt. The ginglymodians were diversified with a large ‘Lepidotes’ plus two obaichthyids and a gar. We confirm Pifithrin-αPifithrin-α inhibitor here that this gar belongs to a genus distinctive from Recent gars, contrary to what was suggested recently. Teleosteans comprise a poorly known ichthyodectiform, a notopterid, a probable osteoglossomorph and a large tselfatiiform, whose cranial anatomy is detailed. The body size and trophic level for each taxon are estimated on the basis of comparison with extant closely related taxa. We plotted the average body size versus average trophic level for the Kem Kem assemblage, together with extant marine and freshwater assemblages. The Kem Kem assemblage is characterized by taxa of proportionally large body size, and by a higher average trophic level than the trophic level of the extant compared freshwater ecosystems, but lower than for the extant marine ecosystems. These results should be regarded with caution because they rest on a reconstructed assemblage known mostly by fragmentary remains. They Selleckchem ML323 reinforce, however, the ecological

oddities already noticed for this mid-Cretaceous vertebrate ecosystem in North Africa.”
“Background and Aims. Trichostatin A (TSA) is a potent histone deacetylase inhibitor and widely used as a promising anticancer agent. Recently, a novel insight for TSA has been shown to protect the heart from ischemia/reperfusion (I/R) injury in mice, but the underlying mechanism remains unclear. The purpose of this study is to investigate whether

TSA can influence endoplasmic reticulum stress (ERS) and whether its cardioprotective effect is mediated by inhibiting myocardial ERS-induced apoptosis in rats.\n\nMethods. Male Wistar rats were used and pretreated with saline or TSA (0.05, 0.1 and 0.2 mg.kg(-1)) once daily i.p. for 5 days. I/R model was established by occlusion/release of the left anterior buy SCH727965 descending coronary artery.\n\nResults. TSA significantly reduced myocardial infarct size and plasma activities of lactate dehydrogenase and creatine kinase in a dose-dependent manner in rats. Accompanied by the reduced injury, TSA also markedly reduced I/R-induced myocardial apoptosis (30 min/24 h) by the TUNEL assay. In addition, increased expression of glucose-regulated protein 78 (an ERS marker) by Western blot showed the effects of TSA on ERS. Induction of C/EBP homologous protein (CHOP), a critical mediator for ERS-induced apoptosis, was attenuated by TSA after reperfusion for 6 h and 24 h.\n\nConclusions.

HPIV-4 had see more year-round prevalence with biennial peaks in odd-numbered years. HPIV-4 and HPIV-3 had similar clinical presentations. 50.8% and 51.5% of patients with HPIV-3-4 had hypoxia compared to 20.3% and 33.3% of patients with HPIV-1-2

(P smaller than .01). HPIV-1 (23.6%) and HPIV-2 (24.2%) were more associated with stridor than HPIV-3 (6.6%) and HPIV-4 (0%) (P smaller than .01). No patients with HPIV-4 had croup. Patients with HPIV-4 had similar lengths of stay and mortality as those with HPIV-1-3. Conclusions. This is the first large-scale analysis of HPIV-4 clinical and epidemiologic features. HPIV-4 was most similar to HPIV-3 in clinical presentation. HPIV-4 had year-round prevalence with peaks in the autumn of odd-numbered selleck chemicals llc years. HPIV-4 is a common respiratory pathogen capable of causing significant morbidity in children.”
“We study the rotational dynamics of a flexible polymer initially wrapped around a rigid rod and unwinding from it. This dynamics is of interest in several problems in biology and constitutes a fundamental instance of polymer relaxation from a state of minimal entropy. We investigate the dynamics of several quantities such as the total and local winding angles and metric quantities. The results of simulations performed

in two and three dimensions, with and without self-avoidance, are explained by a theory based on scaling arguments and on a balance between frictional and entropic forces. The early stage of the

dynamics is particularly rich, being characterized by three coexisting phases.”
“Experimental and computational (DFT) investigations reveal that enyne-allenes with an aryl group as probe at the allene terminus follow a dynamic non-IRC Diels-Alder MI-503 research buy cyclization pathway. Starting from two separate C-2-C-6 (Schmittel) transition states (TS), two distinct reaction paths originate that share a common diradical intermediate, however, without mixing! Because the momentum of the initial TS is transmitted into product formation, we suggest a simple protocol without trajectory computations to estimate the fraction of molecules that follow nonstatistical dynamics: It was calculated from the partitioning at the TSs, as derived from DFT computations, and the experimental ratio. The thus-determined percentage of dynamically reacting molecules only slightly depends on the depth of the intermediate well but rather on Delta Delta G double dagger of the initial and the follow-up transition states.”
“Infections due to extraintestinal pathogenic E. coil (ExPEC) are very common in humans as well as in animals. In humans ExPEC infections include urinary tract infections (UTI), septicemia, and wound infections, which result in significant morbidity, mortality, and substantial healthcare costs. In view of the increasing number of ExPEC infections caused by more and more resistant strains, effective prevention would be desirable.

The research instrument was a questionnaire on socioeconomic data, medical diagnoses, current medication and leading reasons to withdrawals.\n\nResults: From the participants, 67% were male with a mean age of 40 years. The disorders diagnosis, which prevailed, were the ones caused by substance abuse, which is also the main reason of withdrawals from treatment.\n\nConclusion: The active surveillance Cl-amidine in vivo revealed that psychoactive substance dependents are more prevalent in treatment withdrawals.”
“Some species face greater anthropogenic threats than others, and have increased need for scarce conservation resources. Yet how resources are allocated for conservation

remains little known. I examined the distribution of research effort, an index of resource allocation, across Felidae (the cat family), a diverse, widely-distributed, and threatened taxon. I performed complete searches of the published literature for all cat species GDC-0068 cell line from 1986 to 2007, collecting a total of 2,462 papers, of which 926 represented in situ studies. Threat status, as ranked by a World Conservation Union report in 1996, was significantly correlated with geographical range size, with narrowly distributed species tending to be more at risk. Unlike in many other taxa, threat status was not correlated with body size.

The number of total and in situ publications (“research effort”) per species was significantly and positively FAK inhibitor related to body size, but not to threat status or geographical range size. Research effort, rather than being distributed according to actual threat status, is highly skewed towards large species. However, the ratio of the number of studies on the 10 smallest cat species to the number on the 10 largest species has increased significantly since 1986. Yet many species remain severely

understudied; I identify 14 cat species that are threatened and have < 10 in situ publications each. These species critically require a greater share of the conservation research effort.”
“Background For most patients with severely ankylosed hips, traditional surgical approaches do not provide sufficient exposure during THAs. We report our experience with a combined anterior and posterior approach using a lateral incision for total hip arthroplasty (THA) in patients with severe, spontaneous bony hip ankylosis. Methods Between January 2004 and December 2008, patients with severe, spontaneous bony hip ankylosis underwent THA via a combined anterior and posterior approach using a lateral incision. Results We included 47 patients (76 hips) with a mean age of 53 (range 22-72) years in our study. All surgeries were successful, and no significant postoperative complications occurred. The mean operative duration was 1.5 (range 1.3-1.7) hours, and mean blood loss was 490 (range 450-580) mL. The mean duration of follow-up was 5.5 (range 2-11) years.