Nur77 plays a key role at all levels of the hypothalamus-pituitary-adrenal axis during the stress response.

However, the participation of Nur77 in extra-hypothalamic responses to stress is unknown. In this study, we studied the impact of acute and repeated immobilization stress on Nur77 expression in the bed nucleus of stria terminalis (BNST), a region involved in autonomic, neuroendocrine, and behavioral responses to stress. After a single session of immobilization stress we observed a significant increase of Nur77-like immunoreactivity Compound C in the BNST. This effect is not lost with repeated exposure to stress, since Nur77-like immunoreactivity and Nur77 mRNA in BNST were increased after the fifteenth stress session. The administration of desipramine, a specific inhibitor of noradrenaline reuptake, prevented the increase in Nur77-like immunoreactivity and mRNA induced by stress in rats subjected to repeated exposure to immobilization stress. Our results show that acute and repeated stress modulates Nur77 expression in BNST and suggest that Nur77 participates in extra-hypothalamic responses to stress.”
“The Wisconsin beta-catenin pathway Inventory of Smoking Dependence

Motives (WISDM) assesses 13 domains of smoking motivation emphasized by diverse theoretical perspectives. Emerging findings support a distinction between four primary dependence motives (PDM) indexing core features of tobacco dependence and nine secondary dependence motives (SDM) indexing accessory features. The current study explored the validity of this distinction using data from two samples (Ns = 50 and BIIB057 mouse 88) of college smokers who self-monitored their reasons for smoking with electronic diaries. PDM scores were associated with diary endorsement of habitual or automatic motives for smoking individual cigarettes, which are conceptually consistent with the content of the PDM subscales. SDM did not clearly predict conceptually related self-monitored motives

when tested alone. However, when these two correlated scale composites were co-entered, PDM predicted being a daily vs. nondaily smoker, being higher in nicotine dependence, and smoking individual cigarettes because of habit or automaticity. Conversely, after PDM-SDM co-entry, the unique variance in the SDM composite predicted the tendency to report smoking individual cigarettes for situational or instrumental motives (e.g., to control negative affect). The results suggest that the PDM composite may reflect core motivational features of nicotine dependence in these young smokers. The relative prominence of primary motives in advanced or dependent use may be even clearer when motives for smoking are assessed in real time rather than reported via questionnaire. (c) 2010 Elsevier Ireland Ltd. All rights reserved.”
“The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not.

She was treated with repetitive thrombolysis after surgical embolectomy of the brachial artery. The second patient was symptomatic with splenic infarction and mesenteric ischemia. She was treated with a single cycle of systemic thrombolysis followed by ileocoecal resection. The third patient presented with a TAMT obstructing the left common carotid artery, causing ischemic stroke. After systemic thrombolysis, a reduction in thrombus size was documented; however, the patient died later, of acute heart failure, during the clinical course. On follow-up 6 months after the incidences, the 2 surviving patients were in good condition and free

of thromboembolic events. We show that Ubiquitin inhibitor systemic thrombolytic therapy https://www.selleckchem.com/products/p5091-p005091.html can be performed successfully in patients with TAMT.”
“PURPOSE: To determine the efficacy of light-adjustable intraocular lenses (IOL) in correcting residual spherical and cylindrical errors in patients with axial myopia.

SETTING: Center for Vision Science, Ruhr University Eye Clinic, Bochum, Germany.

DESIGN: Prospective cohort study.

METHODS: Light-adjustable IOLs were implanted in eyes with axial myopia and treated with spatial irradiance profiles delivered by a digital light-delivery

device to induce a target spherical and/or spherocylindrical refractive change. Once the desired correction was achieved, the power of the IOL was locked in (ie, photo locking). The manifest refraction, uncorrected distance visual acuity (UDVA), and corrected distance visual acuity (CDVA) were determined 1, 6, and 12 months after lock-in to determine the achieved refractive corrections and their stability.

RESULTS: Twelve months postoperatively, 20 (96%) of the 21 eyes

studied were within +/- 0.50 diopter (D) of the intended selleck chemicals refractive outcome and 17 (81%) were within +/- 0.25 D. One eye had a 0.325 D change in mean refractive spherical equivalent (MRSE). The change in MRSE in the other 20 eyes was less than 0.250 D between 1 month after lock-in and the 3-, 6-, and 12-month postoperative visits.

CONCLUSIONS: The light-adjustable IOL reduced postoperative spherical and cylindrical errors of up to 2.00 D. Postoperative refractive errors were successfully corrected, and there was a significant improvement in UDVA with concomitant maintenance of CDVA. The achieved refractive change was stable after the adjustment and lock-in procedures.”
“Cells need to adapt to the external environment in order to survive. Signal transduction pathways are crucial mechanisms that allow cells to sense and respond to extracellular stimuli. Among the signal transduction pathways, we point out the cascades mediated by mitogen-activated protein kinases (MAPKs). The MAPKs are conserved from yeast to human and play relevant roles in the physiology of the cell. In pathogenic fungi these MAPK pathways control virulence factors.

The extra electrons appear to originate

from a change in the local bonding configuration of V at the LDN-193189 cell line La-O terminated substrate surface as determined by Z-contrast imaging. (C) 2011 American Institute of Physics. [doi:10.1063/1.3601870]“
“Background: The renin-angiotensin system (RAS) has been implied in the pathogenesis of various diseases including acute and chronic pancreatitis. Angiotensin-converting enzyme (ACE) is the key enzyme in activating the RAS. Deletion (D)-type polymorphism in the 16th intron of the ACE gene has been associated with higher serum levels of the enzyme. Inhibition of ACE was found to ameliorate acute pancreatitis in animal models suggesting that ACE plays a role in pathogenesis and progression

of acute pancreatitis. Objectives were to investigate the occurrence of the ACE insertion/deletion (I/D) polymorphism in acute pancreatitis patients and its association with the severity of the disease.

Material and Methods: Seventy-nine acute pancreatitis patients and 95 healthy controls were evaluated. Acute pancreatitis cases were grouped as mild or severe according to the Atlanta criteria. Main outcome measure: The presence of the ACE I/D polymorphism.

Results: ACE gene I and D allele Hippo pathway inhibitor frequency of patients (44% and 56%) were similar to controls (45% and 55%, respectively). There were no significant differences in severity of pancreatitis between patients with the ACE-insertion or ACE-insertion/deletion versus ACE-deletion genotypes.

Conclusions: The ACE gene deletion polymorphism is neither a risk

factor for development of acute pancreatitis nor contributes to the severity of disease or development of complications.”
“BACKGROUND: No prior reports documenting the safety and diagnostic yield of cardiac catheterization and endomyocardial biopsy (EMB) in heart transplant recipients include multicenter data.

METHODS: Data on the safety and diagnostic yield of EMB procedures performed in heart transplant recipients were recorded in the Congenital Cardiac Catheterization Outcomes Project database at 8 pediatric centers during a 3-year period. Adverse events (AEs) were classified according to a 5-level severity scale. Generalized estimating equation models identified risk factors for high-severity AEs (HSAEs; Levels 3-5) and non-diagnostic biopsy samples.

RESULTS: A total of 2,665 EMB cases were performed in 744 A-1155463 price pediatric heart transplant recipients (median age, 12 years [interquartile range, 4.8, 16.7]; 54% male). AEs occurred in 88 cases (3.3%), of which 28 (1.1%) were HSAEs. AEs attributable to EMB included tricuspid valve injury, transient complete heart block, and right bundle branch block. Amongst 822 cases involving coronary angiography, 10 (1.2%) resulted in a coronary-related AE. There were no myocardial perforations or deaths. Multivariable risk factors for HSAEs included fewer prior catheterizations (p = 0.006) and longer case length (p < 0.001).

Heritability and bivariate genetic and environmental correlations were assessed by Sequential Oligogenic Linkage Analysis routines in 1012 family members. We examined 1943 tagging single-nucleotide polymorphisms in 233 inflammatory pathway genes with >= 5 minor allele carriers using a general genetic linear model. Clinical correlates explained 2.4% (CD40 ligand) to 28.5% (C-reactive protein) of the variability in inflammatory biomarkers. Estimated heritability ranged from 10.9% (isoprostanes) to 44.8% (P-selectin). Most correlations between

biomarkers were weak although statistically significant. A total of 45 single-nucleotide polymorphism-biomarker associations met the q-value threshold of 0.25. Novel top single-nucleotide polymorphisms LY2835219 chemical structure were observed in ICAM1 gene CA3 datasheet in relation to intercellular adhesion molecule-1 concentrations (rs1799969, P = 1.32 x 10(-8)) and MPO in relation to myeloperoxidase (rs28730837, P = 1.9 x 10(-5)). Lowest P values for trans-acting single-nucleotide polymorphisms were observed for APCS with monocyte chemoattractant protein-1 concentrations (rs1374486, P = 1.01 x 10(-7)) and confirmed for IL6R with interleukin-6 concentrations (rs8192284, P = 3.36 x 10(-5)). Novel potential candidates (APCS, MPO) need to be replicated.

Conclusions-Our community-based

data support the relevance of clinical

and genetic factors for explaining variation in inflammatory biomarker traits. (Circ Cardiovasc Genet. 2009; 2: 229-237.)”
“Objectives: To evaluate the influence of planning endovascular aneurysm repair (EVAR) with a three-dimensional Bcl-2 inhibitor (3D) workstation on early and midterm outcomes.

Methods: All patients undergoing infrarenal EVAR performed between 2006 and 2009 at our institution were included in the current study. Prior to 2008 (group 1), endograft sizing was performed by interrogation of computed tomography angiography axial images. After 2008 (group 2), endograft sizing was routinely performed using a 3D workstation (Aquarius, Terarecon), allowing for multiplanar reconstruction and centerline analysis. Pre-, perk, postoperative, and follow-up data were prospectively entered in an electronic database. All postoperative complications and subsequent secondary interventions depicted during the 2-year period following EVAR were compared. Secondary intervention and mortality rates were defined at 2 years and compared. Freedom from secondary intervention and overall survival rates were calculated using the Kaplan-Meier method during follow-up and compared by log-rank test.

Results: A total of 295 patients (149 patients in group 1 and 146 patients in group 2) were included.

Two in-hospital deaths occurred, and five patients died during follow-up.

Patients were followed for 1 year after treatment. Eight (9 %) patients treated conservatively had a mild degree of back pain, and one (1 %) patient presented with mild muscular weakness. Among surgically treated patients, 12 (10 %) had only mild neurological impairment, one foot drop, AZD4547 one cauda equine dysfunction, but 4 were paraplegic. Twenty-seven

(23 %) complained of varying degrees of back pain.

Conservative measures are safe and effective for carefully selected patients without spondylodiscitic complications. Failure of conservative therapy requires surgery that can guarantee thorough debridement, decompression, restoration of spinal alignment, and correction of instability. Surgeons should master various techniques to achieve adequate debridement, and pedicle screw instrumentation may safely be used if needed.”
“Serum and follicular fluid zinc concentrations were investigated in patients undergoing assisted reproductive treatment. No correlation was found between zinc and oestradiol concentrations in serum. At the time of oocyte

retrieval, zinc concentrations in follicular fluid were significantly lower than serum concentrations (P < 0.0001). The expression of the two families of zinc transporters, ZnT and ZiP, as well as the metal regulatory transcription factors, MTF1 and 2, and metallothioneins, which are both involved in regulatory aspects of zinc transport, was assayed in cumulus cells this website and in germinal-vesicle oocytes. Most of the

zinc transporters, metallothioneins and metal regulatory transcription factor are expressed in oocytes and not in cumulus cells. This may indicate an important role for zinc, in particular with potential linking to genome stability during early embryonic development. In contrast, cumulus cells seem to be at the end of their life’s journey, with weak expression of transcriptional activity linked Liproxstatin-1 molecular weight to cellular housekeeping. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Background: Anergia (lack of energy) is a newly delineated, criterion-based geriatric syndrome. Because heart failure (HF) is a common chronic condition among older adults and a because a cardinal symptom of HF is reduced energy, we characterized the degree of anergia ill subjects with HF and evaluated its relevance to disease severity, functional performance, and quality of life.

Methods and Results: Prospective 3-month cohort study among a convenience sample of 61 Subjects (61 +/- 15 years, 48% women, ejection fraction 41 +/- 16%) with New York Heart Association (NYHA) Class I-III HF were Studied. The criterion for anergia was based on the major criterion “”sits around for lack of eneroy”" and any 2 of 6 minor criteria.

Journal of Human Hypertension

(2009) 23, 718-727; doi: 10.1038/jhh.2009.8; published online 12 March 2009″
“Ferromagnetic resonance, in 7 to 18 GHz frequency range, is used to investigate a series of 11 sputtered Permalloy (Py)/Cu/Co trilayers and Py/Cu/Co/NiO spin valve system. The experimental data, frequency versus applied magnetic field, agree quit well with the theoretical model. The magnetic coupling between Py and Co is found to be ferromagnetic with effective magnetic coupling parameter values increasing from 0.05 to 0.1 erg/cm(2) as the interlayer Cu thickness decreases from 10 to 2 nm. While the magnetic coupling leads to a decrease in the resonance fields, H-R, of the modes, the exchange anisotropy at the Co/NiO interface shifts the mode upwards. However the shift is more important for the optical mode than for the acoustic one. Hysteresis curves, qualitatively, confirm the ferromagnetic coupling. VX-689 manufacturer The antiferromagnetic NiO layer leads

to a slight increase in the coercive field. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3476269]“
“Electrodiagnostic techniques have been utilized in surgery since the early 1960s. These techniques have been primarily used in neurosurgery; however, with the introduction of neuromodulation for voiding dysfunction, these techniques have now found their way into the field of female pelvic medicine. This article will review techniques applicable to evaluate pelvic floor function as it relates to neuromodulation. It will also review Trichostatin A inhibitor the literature describing how these techniques are used to help determine appropriate candidates as well as improve surgical outcomes. A PubMed Fer-1 solubility dmso search was conducted using the terms neuromodulation, Interstim, electrodiagnosis, electrodiagnostic

techniques, electromyography with limits to the pelvic floor, and voiding dysfunction. Eight articles and three abstracts were found that directly related to the use of electrodiagnostic techniques as they apply to neuromodulation. Electrodiagnostic techniques may play a role in helping predict appropriate candidates for neuromodulation as well as improve surgical outcomes.”
“Whether left ventricular mass (LVM) should be normalized to different indexes in relation to body size is still debated. We sought to evaluate the prevalence of left ventricular hypertrophy (LVH) defined by different indexation criteria in a cohort of hypertensive subjects categorized according to body mass index (BMI). A total of 2213 essential hypertensive subjects included in the Evaluation of Target Organ Damage in Hypertension (ETODH) were divided in three groups according to BMI thresholds (<25, 25-29.9 and >= 30 kg m(-2)). All patients underwent extensive investigations including quantitative echocardiography. LVH was defined as an LVM index equal to or higher than (1) 125 g m(-2) in men and 110 g m(-2) in women, (2) 51 g m(-2.7) in men and 47 g m(-2.7) in women.

There are no prospective studies of the efficacy of lysine supplementation to prevent or reduce the incidence of AD. Supplementation with adequate doses of

lysine could prevent the development of AD.”
“Objective

To investigate the changes in sound localization ability in the horizontal plane after canaloplasty in unilateral congenital aural atresia (CAA) patients.

Study Design

Prospective interventional study.

Setting

Tertiary referral center.

Patients

Twenty-eight patients with unilateral CAA were enrolled. All patients had unilateral conductive hearing loss.

Interventions

Canaloplasty.

Main Outcome Measures

Pure tone audiometry, sound localization test, and the Speech, Spatial, and Quality questionnaire (SSQ) were administered preoperatively, 6 and 12 months postoperatively. For the sound localization test, 8 loudspeakers were Navitoclax inhibitor positioned in a circle at 45-degree intervals, and patients were instructed AC220 ic50 to identify the speaker from which sound was coming. Mean correct response rate and mean error degree were calculated for each patient. The correct lateralization rate to the ipsilesional/contralesional stimuli was also calculated.

Results

Mean hearing threshold decreased from preoperatively 63.8 to 39.4 dB 12 months after canaloplasty. Mean correct

response rate and error degree at preoperative evaluation were 26.0% and 60.7 degrees, respectively, and these were respectively improved to 58.5% and 27.8 degrees postoperatively. Respective mean correct lateralization rate to ipsilesional stimuli after canaloplasty improved from 20.6% to 84.0%, and that to contralesional stimuli slightly improved from 93.8% to 98.8%.

Patients with good postoperative hearing (<40 dBHL) showed better sound localization results. In addition, self-assessment scores of spatial domain in the SSQ questionnaire were significantly improved after the operation.

Conclusion

Sound localization

performance improved significantly after canaloplasty. Canaloplasty could provide better ERK screening localization benefit and subjective improvement in spatial sensation to unilateral CAA patients.”
“Background: There is a great need in the treatment of schizophrenia for a drug, or drug combinations, to improve clinical response with fewer serious side effects. The objective of this study was to explore the therapeutic effects and tolerability of the anticonvulsant gabapentin as an adjunctive in the treatment of patients with partially responsive schizophrenia.

Methods: Ten consenting patients with a confirmed Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision diagnosis of schizophrenia were identified. All patients failed at least one 12-week treatment trial with risperidone or olanzapine.

The prevalence of female sexual dysfunction was 73% for those with endometriosis. Univariable analysis identified three potential predictors of female sexual dysfunction: pelvic pain intensity; deep infiltrating endometriosis status; and revised American Society for Reproductive Medicine stages. Multivariable analysis showed that moderate-to-severe pelvic pain (adjusted odds ratio [OR] 3.4, 95% confidence interval [CI] 1.3-8.8) and revised American Society for Reproductive Medicine stage III or IV (adjusted OR 4.4, 95% CI 1.3-15.5) were associated with increased risk of having female sexual dysfunction.

CONCLUSION: Female sexual

GSK1838705A dysfunction is common in women with endometriosis, especially for those with severe pelvic pain and advanced stages of endometriosis. (Obstet Gynecol

2013;121:601-6) DOI: http://10.1097/AOG.0b013e3182835777″
“OBJECTIVE: To estimate whether follow-up with serum human chorionic gonadotropin (hCG) results in fewer unplanned visits and interventions than follow-up with ultrasonography.

METHODS: Women were randomized to either in-clinic serum hCG or ultrasound follow-up after medical abortion. The primary outcome, unplanned interventions and visits, was measured as a composite binary outcome including: additional clinic or emergency room visits, repeat dosing of misoprostol, and surgical evacuation of the uterus. Surveys Selleckchem CA-4948 were administered at initial follow-up and again 1 month after abortion to inquire about unscheduled visits, interventions, and patient satisfaction. Medical records were reviewed for evidence of additional interventions and visits.

RESULTS: A total of 376 patients was randomized. Most participants were white (56%), single (83%), nulliparous (63%), and had completed high school (96%). Average participant age was 26 +/- 6 years and average gestational age was 46 +/- 6 days. Within see more 2 weeks of abortion, there was no significant difference in the rate of unplanned interventions and visits between arms, 8.2% (13/159) in the serum hCG arm compared with 6.6% (10/151) in the ultrasound arm (relative risk 1.23, 95% confidence interval [CI] 0.56-2.73, P=.60). By 4 weeks postabortion,

4.4% (6/135) in the ultrasound arm and 1.4% (2/142) in the hCG arm had undergone surgical evacuation (relative risk 0.32, 95% CI 0.07-1.54, P=.16). The majority in both the serum hCG (88%) and ultrasound (95%) arms was satisfied with their assigned follow-up method.

CONCLUSION: Medical abortion follow-up with serum hCG does not reduce the rate of unplanned interventions and visits compared with ultrasonography. Overall, the number of unplanned interventions is low and both methods of follow-up are acceptable to women.”
“OBJECTIVE: To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone.

“
“Dopamine is a critical modulator of prefrontal cortical function, and it is known to be dysfunctional in schizophrenia. Current hypotheses on schizophrenia highlight developmental aspects and genetic predisposition for the disease; yet, symptom onset typically occurs during adolescence. Several aspects of prefrontal cortical circuits and their modulation by dopamine mature postnatally, as late as during adolescence. Here we review studies assessing the postnatal trajectory of dopamine control of GABA

interneurons, a neuronal population that has been long suspected to be critical for schizophrenia pathophysiology. Dopamine modulation of fast-spiking interneurons changes dramatically during adolescence (postnatal day 45-50 in rats) with D2 agonists switching from being Torin 1 chemical structure mildly inhibitory in prepubertal rats to strongly excitatory in young adult rats. In vivo recordings in adult rats reveal that deep-layer pyramidal neurons respond to endogenous DA release with suppression of firing while interneurons are activated. In adult rats with a neonatal ventral hippocampal lesion (NVHL), an extensively studied developmental

model of schizophrenia, the maturation in the D2 modulation of interneuron physiology fails to occur, LGX818 rendering a disinhibited prefrontal cortex. Abnormal interneuron maturation may therefore impair cognitive function in the adult animal.”
“Most evidence on the motives-alcohol use link has come from cross-sectional research using retrospective assessments. It remains also to be demonstrated whether motives predict drinking in particular circumstances. In the present study, drinking motives assessed 2 weeks prior to a diary study were used to predict the number of drinks on weekend days as reported via short message service (SMS). Multi-level regression models were estimated based on 391 reports from 55 participants (mean age 22.7). The results revealed that enhancement motives but not gender, age, or social, coping, or conformity motives predicted weekend drinking over and

above usual consumption. Consumption and motives together explained more than three-quarters of the inter-individual variance in weekend drinking. To conclude, this study points to a heavy episodic weekend drinking culture of young people who 3 Methyladenine drink large quantities on Friday and Saturday nights apparently because they are seeking fun and excitement. Preventive measures should aim to counteract young people’s drinking at peak times and in high-risk situations. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“We present briefly 2 newborns with Pasteurella multocida meningitis following incidental household exposure to domestic pets and review 36 additional cases from the literature. Of 38 reported cases of P. multocida meningitis during infancy, 18 were less than or equal to I month of age. All but one of the infants less than I month of age had documented exposure to household dogs and/or cats, most only incidentally.

Life satisfaction was measured with the Life Satisfaction Questionnaire (LiSat-9). Spearman correlations and regression analyses were performed. Results: Both Self-esteem and Burden scores were associated with life satisfaction (correlation coefficients 0.35 and -0.74, respectively). An interaction effect was also found (P = .006); spouses who perceived both high

Burden and high Self-esteem reported significantly higher life satisfaction scores (mean 4.2, standard deviation [SD] 0.5) Anlotinib in vitro than spouses who perceived high Burden but low Self-esteem(mean 3.6, SD 0.7). Conclusions: Positive caregiving experiences are related to spouses’ life satisfaction 3 years poststroke and mediate the impact of burden on life satisfaction. Positive caregiving experiences should get more attention in rehabilitation research and practice.”
“Objective: To determine the feasibility of conducting a randomized controlled trial of massage therapy for patients with a new

spinal cord injury Entrectinib in vitro (SCI) during acute inpatient rehabilitation.

Design: A pilot single-center, randomized, single-blind, cross-over clinical trial.

Setting: Free-standing, not-for-profit, comprehensive rehabilitation center specializing in SCI rehabilitation.

Participants: Forty adults ages 18 years and older undergoing acute rehabilitation following an SCI reporting any type of pain.

Intervention: Rehabilitation nurses trained to give broad compression massage (BCM) and a control light contact touch (LCT) treatments. Participants were randomized to receive either BCM or LCT first, in six 20-min treatment sessions over 2 Pictilisib price weeks, with a 1-week washout between the 2-week treatment periods.

Main outcome measures: Primary outcomes were changes in pain intensity and in fatigue, measured daily. Secondary outcomes included depressive symptoms measured by the Patient Health Questionnaire – 9 (PHQ – 9) and an assessment of pain medication usage.

Results: Pain intensity was higher at baseline and reduced more in the LCT-first group

compared with the BCM-first group in period 1 (P = 0.014), although this pattern was not found in period 2 (P = 0.58). LCT and BCM groups did not significantly differ on any secondary measures except PHQ – 9.

Conclusions: This study demonstrates the feasibility of using rehabilitation nurses to provide tactile therapy to patients with an SCI and suggests a model for controlled clinical trials examining the efficacy of massage therapies. Although efficacy was difficult to assess, BCM was safe and well tolerated.”
“Based on the catalyzed by lipase Amano PS kinetic separation of the two-component mixture of diastereomers of (2RS,6R,10R)-6,10,14-trimethylpentadecan-2-ol in the acylation with the succinic anhydride we obtained the (2R,6R,10R)-6,10,14-trimethylpentadecan-2-ol, the sex pheromone of rice moth (Corcyra cephalonica) and its (2S,6R,10R)-diastereomer.